I have found one of my new favorite webcomics: Least I Can Do. While it does have somewhat of a geeky vibe, it is unlike most of the other ones on my list and doesn’t directly relate to gaming. The primary theme of the strip is sexuality, especially the promiscuity of the primary character, Rayne Summers, a modern-day Casanova (thank you Wikipedia!). But, for the most part, its really funny and done by the same people who do Looking For Group (no relation to my website).
I’d recommend starting with issue #1 but note that the art style does change after a while. The content remains consistently great, though. So definitely check it out!